Abstract Regulation of global transcription output is important for normal development and disease, but little is known about the mechanisms involved.DNA topoisomerase I (TOP1) is an enzyme well-known for LED Power Suppliers its role in relieving DNA supercoils for enabling transcription.Here, we report a non-enzymatic function of TOP1 that downreg
Transcriptional deregulation caused by epigenetic or genetic alterations is a major cause of leukemic transformation.The Spi1/PU.1 transcription factor is a key regulator of many steps of hematopoiesis, and limits self-renewal of hematopoietic stem cells.The deregulation of its expression or activity contributes to leukemia, in which Spi1 can be ei
In systems with several effectors, the results of dose-response (DR) experiments are usually assessed by checking them against two hypotheses: independent action (IA) DAILY FACE MOISTURIZER and concentration addition (CA).Both are useful simplifications, but do not represent the only possible responses, and avoid to a large extent the analysis of t
On many occasions, the maximum result of Bouncy Spray Curl Activator a team does not equate to the total maximum individual effort of each athlete (social loafing).Athletes often combine their sports life with an academic one (Dual Career), prioritizing one over the over in a difficult balancing act.The aim of this research is to examine the existe
Consistent high volumetric performance of machine tools is an essential requirement for high-quality machining.Periodic machine tool calibration ensures said performance and allows for timely M.I.C. corrective actions preventing scrap or rework.Reducing the duration of the calibration process decreases associated cost through non-productive downtim